Around 10-15% of the couples are infertile worldwide, making early evaluation and appropriate treatment essential. One of the first investigations performed during female infertility evaluation is hysterosalpingography (HSG).
HSG is a simple imaging procedure for detecting tubal blockage and uterine abnormalities . Although HSG continues to play a valuable role in infertility assessment, newer techniques such as saline infusion sonography (SIS), HyCoSy (Hysterosalpingo – Contrast Sonography),hysteroscopy,laparoscopy with chromopertubation and MRI provide additional information in selected patients and may even offer therapeutic benefits.
This article explains the indications, procedure, advantages, limitations, complications and modern alternatives to HSG.
Hysterosalpingography (HSG) is an imaging procedure that uses fluoroscopy (X-rays) to evaluate the shape and contour of the uterine cavity and patency of the fallopian tubes by introducing a radiopaque dye into the uterus through the cervix. Tubal factors are responsible for almost 30-40% of women’s infertility, making HSG a useful initial investigation.
What does Hysterosalpingography (HSG) mean?
HSG is a special type of X-ray using a dye that is radio-opaque (will show up on an X-ray film), and is used to determine the shape of the uterus and whether the fallopian tubes are open.
The dye is injected through the cervix under an X-ray that is capable of seeing the dye as it passes through the uterus and fallopian tube.
HSG is usually performed between day 6 and day 10 of the menstrual cycle, after menstrual bleeding has stopped but before ovulation, to avoid disturbing an early pregnancy.
What are the indications for the HSG?
Your fertility specialist may recommend HSG for:
- Evaluation of female infertility.
- Suspected tubal blockage
- Recurrent pregnancy loss
- Congenital uterine anomalies.
- Intrauterine adhesions (Asherman syndrome).
- Assessment after tubal reconstructive surgery or sterilization reversal
- Recurrent implantation failure during fertility treatment
- Suspected abnormalities of the uterine cavity
What is the procedure of HSG?
The process is as follows:
- Patient lies on the fluoroscopy table.
- A speculum is inserted into the vagina.
- The cervix is cleaned with an antiseptic solution
- A special cannula or a catheter is inserted through the cervix.
- Contrast dye is slowly injected into the uterus.
- The fluoroscopic X-ray images are taken as the dye fills the uterus and passes through the fallopian tubes.
- Free spillage of contrast into the pelvic cavity indicates that the tubes are patent
- This procedure usually takes 10-20 minutes.
What abnormalities are revealed by HSG?
HSG can identify:
- Tubal blockage – proximal or distal.
- Hydrosalpinx
- Uterine fibroids – submucous type.
- Endometrial polyps.
- Congenital uterine malformations
- Intrauterine adhesions
- Uterine septum.
- Filling defects within the uterine cavity
- Retained Foreign bodies in the uterus.
What are the benefits of HSG?
Advantages include:
- Simple procedure.
- Quick and minimally invasive
- Relatively inexpensive.
- Excellent initial test for tubal patency
- Provides valuable information about the uterine cavity
- Widely available.
- May improve pregnancy rates in selected infertile women
What are the limitations of HSG?
Limitations include:
- Exposure to a small amount of ionizing radiation.
- Mild Discomfort or cramping.
- Tubal spasm may produce false-positive tubal blockage.
- Lack of evaluation of the pelvic conditions like endometriosis.
- Does not evaluate ovarian function
- Cannot assess external uterine contour
What kind of problems can arise following an HSG?
HSG is generally safe, but rare complications include:
- Pelvic infection.
- Allergic reaction to contrast dye
- Vaginal spotting.
- Pelvic pain or cramping
- Vasovagal reaction (temporary dizziness or fainting)
Women at increased risk of pelvic inflammatory disease may be prescribed antibiotics before the procedure
What are some diagnostic tests that are used in addition to or in place of HSG?
There are a number of modern investigations that are also diagnostic.
Saline Infusion Sonography (SIS):
- SIS involves introducing sterile saline into the uterine cavity during transvaginal ultrasound.
Advantages:
- No radiation exposure.
- Visualisation of uterine cavity
- Detects endometrial polyps.
- Detects submucosal fibroids.
- Identifies intrauterine adhesions.
Hysterosalpingo-Contrast Sonography (HYCOSY)
HYCOSY uses ultrasound contrast agents to assess the fallopian tubes without X-rays
Advantages:
- No radiation.
- Evaluates tubal patency.
- Comfortable outpatient procedure.
- Real-time imaging.
Hysteroscopy
Hysteroscopy is considered the gold standard for evaluating the uterine cavity.
Advantages:
- Direct visualization of the uterine cavity
- Simultaneous diagnosis and treatment.
- Removal of polyps
- Adhesiolysis
- Septum resection.
- Targeted biopsy when required.
Laparoscopy with Chromopertubation
During this procedure, methylene blue dye is injected through the cervix while the doctor directly visualizes dye spill from the fallopian tubes.
Advantages:
- Gold standard for tubal assessment
- Diagnosis of endometriosis
- Detects pelvic adhesions
- Evaluates ovarian and pelvic pathology
- Allows simultaneous surgical treatment
MRI:
MRI is not routinely used for infertility evaluation but is useful in selected patients with:
- Complex Mullerian anomalies
- Adenomyosis
- Deep infiltrating endometriosis
- Complex pelvic pathology
What are the merits of HSG with other diagnostic tests?
| Feature |
HSG |
HyCoSy |
Laparoscopy with Chromopertubation |
Hysteroscopy |
|
Tubal patency assessment
|
Excellent
|
Excellent
|
Gold standard (Excellent)
|
Not suitable
|
|
Uterine cavity evaluation
|
Good
|
Good
|
Limited
|
Gold standard
|
|
Radiation exposure
|
Yes
|
No
|
No
|
No
|
|
Therapeutic intervention possible
|
No
|
No
|
Yes
|
Yes
|
|
Invasiveness
|
Low
|
Low
|
Moderate–High
|
Moderate
|
|
Diagnosis of endometriosis
|
No
|
No
|
Gold standard
|
No
|
|
Assessment of pelvic adhesions
|
No
|
No
|
Excellent
|
No
|
|
Requires anesthesia
|
No
|
No
|
Yes
|
Usually Yes
|
|
Outpatient procedure
|
Yes
|
Yes
|
No
|
No
|
When are advanced diagnostic tests preferred ?
Advanced investigations may be recommended when:
- HSG findings are inconclusive.
- Endometriosis is suspected.
- There is a recurrent implantation failure
- Congenital uterine anomalies require confirmation
- There is history of previous pelvic surgery
- Simultaneous diagnosis and treatment are anticipated
Hysterosalpingography remains one of the most valuable first-line investigations in female infertility. It is a quick, safe and cost-effective method for assessing tubal patency and identifying abnormalities within the uterine cavity.
However, HSG has limitations, particularly in diagnosing pelvic diseases such as endometriosis and pelvic adhesions. Modern techniques including HyCoSy, hysteroscopy, laparoscopy, SIS, and MRI provide complementary information and, in many cases, allow diagnosis and treatment during the same procedure.
The choice of investigation should always be individualized based on the patient’s clinical history, symptoms, previous treatments, and the suspected underlying cause of infertility.